Modeling Human Nervous System
-Advancing the technology-
We tackle ongoing challenges in neural organoid models. For instance, one of the challenges is efficient vascularization of human brain organoids, which is the prerequisite for their long-term maturation and functional refinement. We pursue this through various techniques of stem cell biology and neurobiology.
Diseases of Human Nervous System
-Mechanisms and therapy-
We apply neural organoids to understand human neurological diseases. For instance, basing on fused brain organoids recapitulating regional interactions within the human brain, we now can track interneuron migration and axonal projection in a dish. With that, new mechanistic insights at the molecular level can be gained to better understand human neurological diseases.