​Generation of human region-specific brain organoids with medullary spinal trigeminal nuclei. Pang W, Zhu J, Yang K, Zhu X, Zhou W, Jiang L, Zhuang X, Liu Y, Wei J, Lu X, Yin Y, Chen Z, Xiang Y✉. Cell Stem Cell. 2024 Aug 24:S1934-5909(24)00290-X.

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Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1. Tejwani L, Ravindra NG, Lee C, Cheng Y, Nguyen B, Luttik K, Ni L, Zhang S, Morrison LM, Gionco J, Xiang Y, Yoon J, Ro H, Haidery F, Grijalva RM, Bae E, Kim K, Martuscello RT, Orr HT, Zoghbi HY, McLoughlin HS, Ranum LPW, Shakkottai VG, Faust PL, Wang S, van Dijk D, Lim J, Neuron. 2024 Feb 7; 112(3):362-383.

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Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration.Tejwani L, Jung Y, Kokubu H, Sowmithra S, Ni L, Lee C, Sanders B, Lee PJ, Xiang Y, Luttik K, Soriano A, Yoon J, Park J, Ro HH, Ju H, Liao C, Massaro Tieze S, Rigo F, Jafar-Nejad P, Lim J.J Clin Invest. 2023 Jun 29:e138207.

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Modeling human ectopic pregnancies with trophoblast and vascular organoids.Zhao X, Zhang Z, Zhu Q, Luo Y, Ye Q, Shi S, He X, Zhu J, Zhang D, Xia W, Zhang Y, Jiang L, Cui L, Ye Y, Xiang Y, Hu J, Zhang J, Lin CP.Cell Rep. 2023 May 23;42(6):112546. 

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Generation of ventralized human thalamic organoids with thalamic reticular nucleus.Kiral FR, Cakir B, Tanaka Y, Kim J, Yang WS, Wehbe F, Kang YJ, Zhong M, Sancer G, Lee SH, Xiang Y✉, Park IH✉.Cell Stem Cell. 2023 May 4;30(5):677-688.e5.

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Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation.Sun J, Osenberg S, Irwin A, Ma LH, Lee N, Xiang Y, Li F, Wan YW, Park IH, Maletic-Savatic M, Ballas N.Cell Rep. 2023 Jan 31;42(1):111942.

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Editorial: Improving in vitro modeling of human brain with future brain organoids.Barral S✉, Xiang Y✉, Birey F✉.Front Mol Neurosci. 2022 Aug 9;15:997119.

 

Dyslexia associated gene KIAA0319 regulates cell cycle during human neuroepithelial cell development.Paniagua S, Cakir B, Hu Y, Kiral FR, Tanaka Y, Xiang Y, Patterson B, Gruen JR, Park IH.Front Cell Dev Biol. 2022 Aug 9;10:967147. 

 

Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids.Cakir B, Tanaka Y, Kiral FR, Xiang Y, Dagliyan O, Wang J, Lee M, Greaney AM, Yang WS, duBoulay C, Kural MH, Patterson B, Zhong M, Kim J, Bai Y, Min W, Niklason LE, Patra P, Park IH.Nat Commun. 2022 Jan 20;13(1):430.

 

Modeling human neurodevelopmental diseases with brain organoids.Lu X, Yang J, Xiang Y✉.Cell Regen. 2022 Jan 4;11(1):1.

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Early-career researchers in the time of COVID-19: Starting a new lab during a pandemic.Tikhonova A✉, Xiang Y✉, Gifford C✉.Cell Stem Cell. 2021 May 6;28(5):808-810.

 

Exploration of alcohol use disorder-associated brain miRNA-mRNA regulatory networks.Lim Y, Beane-Ebel JE, Tanaka Y, Ning B, Husted CR, Henderson DC, Xiang Y, Park IH, Farrer LA, Zhang H.Transl Psychiatry. 2021 Oct 2;11(1):504.

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Deconstructing and reconstructing the human brain with regionally specified brain organoids.Xiang Y✉, Cakir B, Park IH✉.Semin Cell Dev Biol. 2021 Mar;111:40-51. 

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Introductions to the Community: Early-Career Researchers in the Time of COVID-19.Smith Q✉, McKinley KL✉, Chan CJ✉, Sikandar S✉, Xiang Y✉, Passaro D✉.Cell Stem Cell. 2020 Nov 5;27(5):702-704.

 

Generation of Regionally Specified Human Brain Organoids Resembling Thalamus Development.Xiang Y✉, Cakir B, Park IH✉.STAR Protoc. 2020 Jun 19;1(1):100001. 

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Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons.Xiang Y*, Tanaka Y*, Patterson B, Hwang SM, Hysolli E, Cakir B, Kim KY, Wang W, Kang YJ, Clement EM, Zhong M, Lee SH, Cho YS, Patra P, Sullivan GJ, Weissman SM, Park IH.Mol Cell. 2020 Jul 2;79(1):84-98.e9.

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Synthetic Analyses of Single-Cell Transcriptomes from Multiple Brain Organoids and Fetal Brain.Tanaka Y, Cakir B, Xiang Y, Sullivan GJ, Park IH.Cell Rep. 2020 Feb 11;30(6):1682-1689.e3.

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Engineering of human brain organoids with a functional vascular-like system.Cakir B*, Xiang Y*, Tanaka Y, Kural MH, Parent M, Kang YJ, Chapeton K, Patterson B, Yuan Y, He CS, Raredon MSB, Dengelegi J, Kim KY, Sun P, Zhong M, Lee S, Patra P, Hyder F, Niklason LE, Lee SH, Yoon YS, Park IH.Nat Methods. 2019 Nov;16(11):1169-1175.

 

hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids.Xiang Y*, Tanaka Y*, Cakir B, Patterson B, Kim KY, Sun P, Kang YJ, Zhong M, Liu X, Patra P, Lee SH, Weissman SM, Park IH.Cell Stem Cell. 2019 Mar 7;24(3):487-497.e7.

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Generation and Fusion of Human Cortical and Medial Ganglionic Eminence Brain Organoids.Xiang Y*, Yoshiaki T, Patterson B, Cakir B, Kim KY, Cho YS, Park IH.Curr Protoc Stem Cell Biol. 2018 Nov;47(1):e61. 

 

Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a.Kim KY, Tanaka Y, Su J, Cakir B, Xiang Y, Patterson B, Ding J, Jung YW, Kim JH, Hysolli E, Lee H, Dajani R, Kim J, Zhong M, Lee JH, Skalnik D, Lim JM, Sullivan GJ, Wang J, Park IH.Nat Commun. 2018 Jul 3;9(1):2583.

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​Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration.Xiang Y*, Tanaka Y*, Patterson B, Kang YJ, Govindaiah G, Roselaar N, Cakir B, Kim KY, Lombroso AP, Hwang SM, Zhong M, Stanley EG, Elefanty AG, Naegele JR, Lee SH, Weissman SM, Park IH.Cell Stem Cell. 2017 Sep 7;21(3):383-398.e7.