top of page

Selected Publications

*First Author, # Corresponding Author

Selected Publications

Kiral FR, Cakir B, Tanaka Y, Kim J, Yang WS, Wehbe F, Kang YJ, Zhong M, Sancer G, Lee SH, Xiang Y, Park IH. Generation of ventralized human thalamic organoids with thalamic reticular nucleus. Cell Stem Cell. 2023 Mar 28:S1934-5909(23)00078-4. 

Sun J, Osenberg S, Irwin A, Ma LH, Lee N, Xiang Y, Li F, Wan YW, Park IH, Maletic-Savatic M, Ballas N. Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation. CELL REPORTS. 2023 Jan 4;42(1):111942.

Barral S, Xiang Y, Birey F. Editorial: Improving in vitro modeling of human brain with future brain organoids. FRONTIERS IN MOLECULAR NEUROSCIENCE. 09 Aug 2022. 15.


Cakir B, Tanaka Y, Kiral FR, Xiang Y, Dagliyan O, Wang J, Lee M, Greaney AM, Yang WS, duBoulay C, Kural MH, Patterson B, Zhong M, Kim J, Bai Y, Min W, Niklason LE, Patra P, Park IH. Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids. NAT COMMUN. Jan 2022. 13(1):430.

Lu X, Yang J, Xiang Y. Modeling human neurodevelopmental diseases with brain organoids.CELL REGENERATION. 01 Dec 2022. 11(1).

Tikhonova A, Xiang Y, Gifford C. Early-career researchers in the time of COVID-19: Starting a new lab during a pandemic.CELL STEM CELL. 2021 May 6;28(5):808-810.

Smith Q, McKinley KL, Chan CJ, Sikandar S, Xiang Y, Passaro D.Introductions to the Community: Early-Career Researchers in the Time of COVID-19.CELL STEM CELL. Nov 2020. 27(5):702-704.

Xiang Y, Tanaka Y, Patterson B, Hwang SM, Hysolli E, Cakir B, Kim KY, Wang W, Kang YJ, Clement EM, Zhong M, Lee SH, Cho YS, Patra P, Sullivan GJ, Weissman SM, Park IH.Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons.MOLECULAR CELL. 2020. 79(1):84-+.

Xiang Y, Cakir B, Park IH.Deconstructing and Reconstructing the Human Brain With Regionally Specified Brain Organoids.SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 2020.

Tanaka Y, Cakir B, Xiang Y, Sullivan GJ, Park IH.Synthetic Analyses of Single-Cell Transcriptomes From Multiple Brain Organoids and Fetal Brain.CELL REPORTS. 2020. 30(6):1682-1689.

Cakir B, Xiang Y, Tanaka Y, Kural MH, Parent M, Kang YJ, Chapeton K, Patterson B, Yuan Y, He CS, Raredon MSB, Dengelegi J, Kim KY, Sun P, Zhong M, Lee S, Patra P, Hyder F, Niklason LE, Lee SH, Yoon YS, Park IH.Engineering of human brain organoids with a functional vascular-like system.NATURE METHODS. 2019. 16(11):1169.

Xiang Y, Cakir B, Park IH.Generation of regionally specified human brain organoids resembling thalamus development.CELL PRESS: STAR PROTOCOLS. 2019.

Xiang Y, Tanaka Y, Cakir B, Patterson B, Kim KY, Sun P, Kang YJ, Zhong M, Liu X, Patra P, Lee SH, Weissman SM, Park IH.hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids.CELL STEM CELL. 2019. 24(3):487.

Xiang Y, Yoshiaki T, Patterson B, Cakir B, Kim KY, Cho YS, Park IH.Generation and fusion of human cortical and medial ganglionic eminence brain organoids.CURRENT PROTOCOLS IN STEM CELL BIOLOGY. 2018.

Kim KY, Tanaka Y, Su J, Cakir B, Xiang Y, Patterson B, Ding J, Jung YW, Kim JH, Hysolli E, Lee H, Dajani R, Kim J, Zhong M, Lee JH, Skalnik D, Lim JM, Sullivan GJ, Wang J, Park IH.Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a.NATURE COMMUNICATIONS. 2018. 9.

Xiang Y, Tanaka Y, Patterson B, Kang YJ, Govindaiah G, Roselaar N, Cakir B, Kim KY, Lombroso AP, Hwang SM, Zhong M, Stanley EG, Elefanty AG, Naegele JR, Lee SH, Weissman SM, Park IH.Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration.CELL STEM CELL. 2017. 21(3):383.


Graduate course: Principles of Regenerative Medicine (Spring)

Undergrad course: Brain Organoids (Fall)

Undergrad course: Fundamentals of Biomedical Engineering (Fall)

Graduate course: Experimental Biology (Fall) ​

bottom of page